US · guidance
CMS Pub. 100-04, ch. 4, § 230.2
Coding and Payment for Drug Administration
A. Overview
Drug administration services furnished under the Hospital Outpatient Prospective
Payment System (OPPS) during CY 2005 were reported using CPT codes 90780, 90781,
and 96400-96459.
Effective January 1, 2006, some of these CPT codes were replaced with more detailed
CPT codes incorporating specific procedural concepts, as defined and described by the
CPT manual, such as initial, concurrent, and sequential.
Hospitals are instructed to use the full set of CPT codes, including those codes
referencing concepts of initial, concurrent, and sequential, to bill for drug administration
services furnished in the hospital outpatient department beginning January 1, 2007. In
addition, hospitals are instructed to continue billing the HCPCS codes that most
accurately describe the service(s) provided.
Hospitals are reminded to bill a separate Evaluation and Management code (with
modifier 25) only if a significant, separately identifiable E/M service is performed in the
same encounter with OPPS drug administration services.
B. Billing for Infusions and Injections
Beginning in CY 2007, hospitals were instructed to use the full set of drug administration
CPT codes (90760-90779; 96401-96549), (96413-96523 beginning in CY 2008) (96360-
96549 beginning in CY 2009) when billing for drug administration services provided in
the hospital outpatient department. In addition, hospitals are to continue to bill HCPCS
code C8957 (Intravenous infusion for therapy/diagnosis; initiation of prolonged infusion
(more than 8 hours), requiring use of portable or implantable pump) when appropriate.
Hospitals are expected to report all drug administration CPT codes in a manner consistent
with their descriptors, CPT instructions, and correct coding principles. Hospitals should
note the conceptual changes between CY 2006 drug administration codes effective under
the OPPS and the CPT codes in effect beginning January 1, 2007, in order to ensure
accurate billing under the OPPS. Hospitals should report all HCPCS codes that describe
the drug administration services provided, regardless of whether or not those services are
separately paid or their payment is packaged.
Medicare’s general policy regarding physician supervision within hospital outpatient
departments meets the physician supervision requirements for use of CPT codes 90760-
90779, 96401-96549, (96413-96523 beginning in CY 2008). (Reference: Pub.100-02,
Medicare Benefit Policy Manual, Chapter 6, §20.4.)
Drug administration services are to be reported with a line item date of service on the day
they are provided. In addition, only one initial drug administration service is to be
reported per vascular access site per encounter, including during an encounter where
observation services span more than 1 calendar day.
C. Payments For Drug Administration Services
For CY 2007, OPPS drug administration APCs were restructured, resulting in a six-level
hierarchy where active HCPCS codes have been assigned according to their clinical
coherence and resource use. Contrary to the CY 2006 payment structure that bundled
payment for several instances of a type of service (non-chemotherapy, chemotherapy by
infusion, non-infusion chemotherapy) into a per-encounter APC payment, structure
introduced in CY 2007 provides a separate APC payment for each reported unit of a
separately payable HCPCS code.
Hospitals should note that the transition to the full set of CPT drug administration codes
provides for conceptual differences when reporting, such as those noted below.
• In CY 2006, hospitals were instructed to bill for the first hour (and any
additional hours) by each type of infusion service (non-chemotherapy,
chemotherapy by infusion, non-infusion chemotherapy). Beginning in CY 2007,
the first hour concept no longer exists. CPT codes in CY 2007 and beyond allow
for only one initial service per encounter, for each vascular access site, no matter
how many types of infusion services are provided; however, hospitals will receive
an APC payment for the initial service and separate APC payment(s) for
additional hours of infusion or other drug administration services provided that
are separately payable.
• In CY 2006, hospitals providing infusion services of different types (non-chemotherapy, chemotherapy by infusion, non-infusion chemotherapy) received
payment for the associated per-encounter infusion APC even if these infusions
occurred during the same time period. Beginning in CY 2007, hospitals should
report only one initial drug administration service, including infusion services, per
encounter for each distinct vascular access site, with other services through the
same vascular access site being reported via the sequential, concurrent or
additional hour codes. Although new CPT guidance has been issued for reporting
initial drug administration services, Medicare contractors shall continue to follow
the guidance given in this manual.
(NOTE: This list above provides a brief overview of a limited number of
the conceptual changes between CY 2006 OPPS drug administration codes
and CY 2007 OPPS drug administration codes - this list is not comprehensive
and does not include all items hospitals will need to consider during this
transition)
For APC payment rates, refer to the most current quarterly version of Addendum B on
the CMS Web site at http://www.cms.hhs.gov/HospitalOutpatientPPS/.
D. Infusions Started Outside the Hospital
Hospitals may receive Medicare beneficiaries for outpatient services who are in the
process of receiving an infusion at their time of arrival at the hospital (e.g., a patient who
arrives via ambulance with an ongoing intravenous infusion initiated by paramedics
during transport). Hospitals are reminded to bill for all services provided using the
HCPCS code(s) that most accurately describe the service(s) they provided. This includes
hospitals reporting an initial hour of infusion, even if the hospital did not initiate the
infusion, and additional HCPCS codes for additional or sequential infusion services if
needed.
History
(Rev. 2141, Issued: 01-24-11, Effective: 01-01-11, Implementation: 01-03-11)
Provenance
- Source
- cms.gov
- Retrieved
- 2026-08-25
- Edition
- iom-2026-08-25
- Content hash
eb704d799a0a0b2f4f96055f9fc7650119bb98510c74d411b43d670cec3746bc
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